Thursday, March 8th, 2007

Time	Event
2:05p	How A Specific Fat Type Can Protect Against Weight Gain And Diabetes Science Daily — A new study from Joslin Diabetes Center may shed light on why some people can eat excessive amounts of food and not gain weight or develop type 2 diabetes, while others are more likely to develop obesity and this most common form of diabetes on any diet. The study, which used two strains of mice with differing tendencies to gain weight and develop diabetes on a high-fat diet, identified genetic and cellular mechanisms that may prevent certain mice on a calorie-dense diet from gaining weight and developing metabolic syndrome. More here (Comment on this)
2:12p	Insulin -- In Need Of Some Restraint? Science Daily — Knocking out the gene for a peptide associated with insulin secretion protects mice against the harmful effects of a high-fat diet, report researchers at the Salk Institute for Biological Studies. Their findings, detailed in the Proceedings of the National Academy of Sciences, suggest that urocortin 3, a new peptide recently discovered in the insulin secreting cells of the pancreas, plays a role in the increased production of insulin in response to high caloric intake in animals. "Many normal mice eventually develop some signs of type 2 diabetes as they age," explains Wylie Vale, Ph.D., who conducted the study in collaboration with Kuo-Fen Lee, Ph.D., both professors in the Clayton Foundation Laboratories for Peptide Biology. "Interestingly, the mutant mice missing the urocortin 3 gene did not develop the age-related insulin resistance and high blood sugar we observed in the normal control mice," adds Vale. more here (Comment on this)

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